Mtor^tm1.2Koz
Targeted Allele Detail

Summary

• Symbol: Mtor^tm1.2Koz
• Name: mechanistic target of rapamycin kinase; targeted mutation 1.2, Sara C Kozma
• MGI ID: MGI:3850506
• Synonyms: Frap1^fl, mTOR^fl, mTOR^flox
• Gene: Mtor Location: Chr4:148533068-148642140 bp, + strand Genetic Position: Chr4, 78.76 cM, cytoband E1
• Alliance: Mtor^tm1.2Koz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150108
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 5. Transient cre expression in ES cells removed the neo cassette creating this allele. (J:150108, J:162918)

Expression

In Mice Carrying this Mutation:	110 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mtor Mutation: 115 strains or lines available

References

• Original: J:150108 Delgoffe GM, et al., The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 2009 Jun 19;30(6):832-44
• All: 83 reference(s)