Mdm4^tm1.1Wahl
Targeted Allele Detail

Summary

• Symbol: Mdm4^tm1.1Wahl
• Name: transformed mouse 3T3 cell double minute 4; targeted mutation 1.1, Goeff Wahl
• MGI ID: MGI:3850668
• Synonyms: Mdmx^3SA
• Gene: Mdm4 Location: Chr1:132913843-132958325 bp, - strand Genetic Position: Chr1, 57.75 cM, cytoband G-G
• Alliance: Mdm4^tm1.1Wahl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150341
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 11 was replaced with one in which codons for serines 341, 367, and 402 were modified to code for alanines. A floxed neo cassette upstream of the modified exon 11 was used for selection but was removed by cre expression in ES cells. These serines are located at conserved Chk2 sites and are necessary for protein degradation. (J:150341)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mdm4 Mutation: 193 strains or lines available

References

• Original: J:150341 Wang YV, et al., Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases. Cancer Cell. 2009 Jul 7;16(1):33-43
• All: 1 reference(s)