Grin2c^tm2Rsp
Targeted Allele Detail

Summary

• Symbol: Grin2c^tm2Rsp
• Name: glutamate receptor, ionotropic, NMDA2C (epsilon 3); targeted mutation 2, Rolf Sprengel
• MGI ID: MGI:3850683
• Synonyms: NR2C^-
• Gene: Grin2c Location: Chr11:115139995-115158069 bp, - strand Genetic Position: Chr11, 80.8 cM
• Alliance: Grin2c^tm2Rsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45446
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin selection cassette replaced a part of intron 4 and exon 5. (J:45446)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin2c Mutation: 56 strains or lines available

References

• Original: J:45446 Sprengel R, et al., Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell. 1998 Jan 23;92(2):279-89
• All: 3 reference(s)