Grik4^tm1(cre)Mim
Targeted Allele Detail

Summary

• Symbol: Grik4^tm1(cre)Mim
• Name: glutamate receptor, ionotropic, kainate 4; targeted mutation 1, Masayoshi Mishina
• MGI ID: MGI:3850720
• Synonyms: GluRgamma1^cre
• Gene: Grik4 Location: Chr9:42431708-42856296 bp, - strand Genetic Position: Chr9, 23.8 cM
• Alliance: Grik4^tm1(cre)Mim page

Increased susceptibility to kainate-induced tonic-clonic seizures in Grin1^tm1Mim/Grin1^tm1Mim Grik4^tm1(cre)Mim/Grik4⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144994
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Grik4^tm1(cre)Mim expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Grik4 (MGI:95817)

• Mutation details: The cre gene was inserted into the translational initiation site of the gene. An frt-flanked neo cassette followed the cre gene. Expression of cre is restricted to hippocampal CA3 pyramidal neurons and does not recapitulate the expression of the endogenous gene, presumably due to the neo cassette insertion. (J:144994)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Grik4 (mouse) Summary of all recombinase alleles driven by Grik4. Alliance mouse Grik4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grik4 Mutation: 48 strains or lines available

References

• Original: J:144994 Fukushima F, et al., Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons. PLoS One. 2009;4(1):e3993
• All: 1 reference(s)