Ightm2.1(Tag)Rwhe
Targeted Allele Detail
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Symbol: |
Ightm2.1(Tag)Rwhe |
Name: |
immunoglobulin heavy chain complex; targeted mutation 2.1, Rudolf Hendriks |
MGI ID: |
MGI:3850723 |
Synonyms: |
IgH.TEmu |
Gene: |
Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic
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Germline Transmission: |
Earliest citation of germline transmission:
J:150315
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Inserted expressed sequence) |
Mutation: |
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Insertion
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Mutation details: A floxed neomycin resistance gene, a splice accepter, an internal ribosome entry site, a SV40 large and small T antigen coding region, and an extra copy of the IgH intronic
enhancer Emu were inserted in a reverse orientation between DQ52 and JH1 in the IgH locus. The neomycin gene was removed after targeting by crossing founder mice with transgenic mice expressing cre in the germline. SV40 T antigen transcripts were detected by RT-PCR in B cells.
(J:150315)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Igh Mutation: |
44 strains or lines available
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Original: |
J:150315 ter Brugge PJ, et al., A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen. Blood. 2009 Jul 2;114(1):119-27 |
All: |
5 reference(s) |
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