Hprt1^{tm1(Rcan1)Zyga}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(Rcan1)Zyga}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Zygmunt Galdzicki
• MGI ID: MGI:3850734
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(Rcan1)Zyga} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150286
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Hprt1^{tm1(Rcan1)Zyga} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rcan1 (MGI:1890564)

• Mutation details: The non-functional exon 1 was replaced with a myc-tagged Rcan1 cDNA, 2 kb of the native Rcan1 promoter, and a functional Hprt exon 1. (J:150286)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:150286 Baek KH, et al., Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature. 2009 Jun 25;459(7250):1126-30
• All: 6 reference(s)