Rftn1^tm1Ayos
Targeted Allele Detail

Summary

• Symbol: Rftn1^tm1Ayos
• Name: raftlin lipid raft linker 1; targeted mutation 1, Akihiko Yoshimura
• MGI ID: MGI:3850829
• Synonyms: Raftlin^-
• Gene: Rftn1 Location: Chr17:50300287-50497525 bp, - strand Genetic Position: Chr17, 25.86 cM
• Alliance: Rftn1^tm1Ayos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150299
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The second exon that encodes the first 48 amino acids of the gene product were replaced with a neomycin cassette. Gene inactivation was confirmed by immunoblot analysis on thymus, spleen and bone marrow extracts. (J:150299)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rftn1 Mutation: 50 strains or lines available

References

• Original: J:150299 Saeki K, et al., A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses. J Immunol. 2009 May 15;182(10):5929-37
• All: 3 reference(s)