Tg(Lck/Emu-Rftn1)1Ayos
Transgene Detail

Summary

• Symbol: Tg(Lck/Emu-Rftn1)1Ayos
• Name: transgene insertion 1, Akihiko Yoshimura
• MGI ID: MGI:3850830
• Synonyms: Raftlin-Tg
• Transgene: Tg(Lck/Emu-Rftn1)1Ayos Location: unknown
• Alliance: Tg(Lck/Emu-Rftn1)1Ayos page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck/Emu-Rftn1)1Ayos expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rftn1 (MGI:1923688)

• Mutation details: Murine Rftn1 coding sequence was placed under the control of a Lck proximal promoter that contained an IgH intronic chain enhancer Emu. 3' untranslated human growth hormone sequence was included downstream. Transgenic expression in B and T cells was confirmed by immunoblot analysis. (J:150299)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:150299 Saeki K, et al., A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses. J Immunol. 2009 May 15;182(10):5929-37
• All: 1 reference(s)