Git1^tm1.2Rtp
Targeted Allele Detail

Summary

• Symbol: Git1^tm1.2Rtp
• Name: GIT ArfGAP 1; targeted mutation 1.2, Richard T Premont
• MGI ID: MGI:3850987
• Synonyms: Git1^del
• Gene: Git1 Location: Chr11:77384388-77398612 bp, + strand Genetic Position: Chr11, 46.61 cM
• Alliance: Git1^tm1.2Rtp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150460
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and a floxed hsv-tk and pgk-neo cassette was inserted into intron 7. Cre mediated recombination removed the hsv-tk and pgk-neo cassette and exons 2 -7, leaving a single loxP site. Western blot analysis confirmed the absence of protein expression in cerebellar lysates from homozygous mice. (J:150460)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Git1 Mutation: 42 strains or lines available

References

• Original: J:150460 Schmalzigaug R, et al., Impaired fear response in mice lacking GIT1. Neurosci Lett. 2009 Jul 17;458(2):79-83
• All: 2 reference(s)