Cul4a^tm1.2Pz
Targeted Allele Detail

Summary

• Symbol: Cul4a^tm1.2Pz
• Name: cullin 4A; targeted mutation 1.2, Pengbo Zhou
• MGI ID: MGI:3851025
• Synonyms: Cul4a^-
• Gene: Cul4a Location: Chr8:13155623-13197940 bp, + strand Genetic Position: Chr8, 5.73 cM
• Alliance: Cul4a^tm1.2Pz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150427
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Mice containing the allele Cul4a^tm1.1Pz were crossed with Ella-cre transgenic mice to excise the floxed exons 17-19 from germline cells. A C-terminal truncated protein was detected at 8% of endogenous levels in homozygote embryonic fibroblasts by immunoblot analysis. This protein product failed to interact with RBX1 for recruitment of the E2 ubiquitin-conjugating enzyme and thus was considered functionally null. (J:150427)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cul4a Mutation: 30 strains or lines available

References

• Original: J:150427 Liu L, et al., CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol Cell. 2009 May 14;34(4):451-60
• All: 2 reference(s)