Foxp2^tm1Woen
Targeted Allele Detail

Summary

• Symbol: Foxp2^tm1Woen
• Name: forkhead box P2; targeted mutation 1, Wolfgang Enard
• MGI ID: MGI:3851106
• Synonyms: Foxp2^hum
• Gene: Foxp2 Location: Chr6:14901348-15441976 bp, + strand Genetic Position: Chr6, 6.49 cM, cytoband A2
• Alliance: Foxp2^tm1Woen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150425
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Duplication, Insertion, Nucleotide substitutions
• Foxp2^tm1Woen involves 1 genes/genome features (Foxp2) View all
• Mutation details: Exon 7 was replaced with a frt flanked neo cassette with a 5' loxP site and a modified exon 7 followed by a 3' loxP site. The modified exon 7 contains nucleotide substitutions that result in two amino acid substitutions, namely, asparagine for threonine at position 302 (T302N), and serine for asparagine at position 324 (N324S). These amino acid substitutions mimic the amino acids found in humans. Southern blot analysis revealed a duplication/rearrangement within the 3' portion of the gene. (J:150425)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp2 Mutation: 52 strains or lines available

References

• Original: J:150425 Enard W, et al., A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell. 2009 May 29;137(5):961-71
• All: 4 reference(s)