Foxp2^tm2.2Woen
Targeted Allele Detail

Summary

• Symbol: Foxp2^tm2.2Woen
• Name: forkhead box P2; targeted mutation 2.2, Wolfgang Enard
• MGI ID: MGI:3851108
• Synonyms: Foxp2^ko
• Gene: Foxp2 Location: Chr6:14901348-15441976 bp, + strand Genetic Position: Chr6, 6.49 cM, cytoband A2
• Alliance: Foxp2^tm2.2Woen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150425
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removed exon 7. The absence of protein expression was confirmed by western blot analysis on embryo extracts. (J:150425)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp2 Mutation: 52 strains or lines available

References

• Original: J:150425 Enard W, et al., A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell. 2009 May 29;137(5):961-71
• All: 3 reference(s)