Cplx4^tm1Bros
Targeted Allele Detail

Summary

• Symbol: Cplx4^tm1Bros
• Name: complexin 4; targeted mutation 1, Nils Brose
• MGI ID: MGI:3851151
• Gene: Cplx4 Location: Chr18:66088793-66103249 bp, - strand Genetic Position: Chr18, 39.05 cM
• Alliance: Cplx4^tm1Bros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150490
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in the retinas from homozygous mice. (J:150490)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cplx4 Mutation: 19 strains or lines available

References

• Original: J:150490 Reim K, et al., Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4. J Cell Sci. 2009 May 1;122(Pt 9):1352-61
• All: 5 reference(s)