Tg(Scn1a*)RH9Aesc
Transgene Detail
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Symbol: |
Tg(Scn1a*)RH9Aesc |
Name: |
transgene insertion RH9, Andrew Escayg |
MGI ID: |
MGI:3851210 |
Synonyms: |
Scn1aTg-RH9 |
Transgene: |
Tg(Scn1a*)RH9Aesc Location: unknown
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Alliance: |
Tg(Scn1a*)RH9Aesc page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Scn1a*)RH9Aesc expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Scn1a (MGI:98246) |
R1648H substitution |
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Mutation details: A BAC (clone 259E13) of size 187 kb containing mouse genomic sequence extending from 115 kb upstream of the Scn1a translation start site to 3 kb downstream from the polyA termination signal was modified to add a FLAG tag, an E954Q substitution (confering TTX and STX resistance), and an R1648H substitution (homologous to a mutation seen in human patients with Generalized Epilepsy with Febrile Seizures Plus). Two lines were generated, RH5 and RH9. Line RH9 had the highest level of transgene expression.
(J:150454)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:150454 Tang B, et al., A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation. Neurobiol Dis. 2009 Jul;35(1):91-102 |
All: |
1 reference(s) |
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