Muc2^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Muc2^M1Btlr
• Name: mucin 2; mutation 1, Bruce Beutler
• MGI ID: MGI:3851216
• Synonyms: Schlendrian
• Gene: Muc2 Location: Chr7:141276583-141308428 bp, + strand Genetic Position: Chr7, 87.1 cM, cytoband F5
• Alliance: Muc2^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was identified in a screen of G3 progeny of an ENU mutagenized male mouse for susceptibility to induction of colitis by dextran sulfate sodium (DSS) (DSS-induced Colitis Screen). The mutation comprises a G to T transversion at nucleotide position 1711, in the 13th of the gene's 47 exons. It is predicted to result in substitution, at amino acid position 561, of phenylalanine for a conserved cysteine in the second von Willebrand factor type D (VWFD) domain of the protein. (J:150326)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Muc2 Mutation: 84 strains or lines available

References

• Original: J:150326 Brandl K, et al., Record for "Schlendrian", updated July 1st, 2009. MGI Direct Data Submission. 2009
• All: 1 reference(s)