Lmo7^tm1Miyo
Targeted Allele Detail

Summary

• Symbol: Lmo7^tm1Miyo
• Name: LIM domain only 7; targeted mutation 1, Jun Miyoshi
• MGI ID: MGI:3851221
• Gene: Lmo7 Location: Chr14:101967393-102172146 bp, + strand Genetic Position: Chr14, 50.9 cM
• Alliance: Lmo7^tm1Miyo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150612
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 8 and exon 9 that encode for the PDZ domain were replaced with a neo cassette. The absence of full-length protein expression was confirmed by western blot analysis and immunohistochemistry of lung tissues. (J:150612)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmo7 Mutation: 106 strains or lines available

References

• Original: J:150612 Tanaka-Okamoto M, et al., Increased susceptibility to spontaneous lung cancer in mice lacking LIM-domain only 7. Cancer Sci. 2009 Apr;100(4):608-16
• All: 2 reference(s)