Treml1^tm1Mcvic
Targeted Allele Detail

Summary

• Symbol: Treml1^tm1Mcvic
• Name: triggering receptor expressed on myeloid cells-like 1; targeted mutation 1, Daniel W McVicar
• MGI ID: MGI:3851246
• Synonyms: Tlt1^-
• Gene: Treml1 Location: Chr17:48666944-48674204 bp, + strand Genetic Position: Chr17, 23.99 cM, cytoband C
• Alliance: Treml1^tm1Mcvic page

Increased hemorrhage associated with inflammation in Treml1^tm1Mcvic/Treml1^tm1Mcvic mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150578
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 1 and 2 were replaced with a floxed neomycin cassette. The absence of the protein was determined by Western blot and confocal analysis on homozygote tissues (J:150578)

Generation of the Treml1^tm1Mcvic allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Treml1 Mutation: 29 strains or lines available

References

• Original: J:150578 Washington AV, et al., TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J Clin Invest. 2009 Jun;119(6):1489-501
• All: 2 reference(s)