Tg(Myh6-CYP2J2)#Dcz
Transgene Detail

Summary

• Symbol: Tg(Myh6-CYP2J2)#Dcz
• Name: transgene insertion #, Darryl Zeldin
• MGI ID: MGI:3851346
• Transgene: Tg(Myh6-CYP2J2)#Dcz Location: unknown
• Alliance: Tg(Myh6-CYP2J2)#Dcz page

Transgene origin

• Strain of Origin: C57BL/6NTac

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene consists of human CYP2J2 cDNA cloned into a vector containing the mouse alpha-MHC promoter and human growth hormone intron and polyA sequence to drive cardiomyocyte-specific expression of the transgene. Six germline founder mice lines, Tr2, Tr3, Tr4, Tr5, Tr6, and Tr7 were generated. Of those 6 germline founders, 4 lines, Tr2, Tr3, Tr5, and Tr7 had abundant cardiac expression of the transgene. Heterozygous transgenic progeny of each of these four overexpressing lines were analyzed and data are presented as a pool of all four lines. (J:101489)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:101489 Seubert J, et al., Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. Circ Res. 2004 Sep 3;95(5):506-14
• All: 13 reference(s)