Stk39^tm1Dlp
Targeted Allele Detail

Summary

• Symbol: Stk39^tm1Dlp
• Name: serine/threonine kinase 39; targeted mutation 1, Eric Delpire
• MGI ID: MGI:3851398
• Gene: Stk39 Location: Chr2:68040789-68302381 bp, - strand Genetic Position: Chr2, 39.53 cM, cytoband C3
• Alliance: Stk39^tm1Dlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150513
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion Mutation details: A cassette, containing tyrosinase, floxed 5' Hprt, and neo genes along with an additional copy of exon 6, was inserted downstream of exon 6. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:150513)

Generation of the Stk39^tm1Dlp allele

Expression

In Mice Carrying this Mutation:	48 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk39 Mutation: 42 strains or lines available

References

• Original: J:150513 Geng Y, et al., The Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neurons. J Biol Chem. 2009 May 22;284(21):14020-8
• All: 16 reference(s)