Rfx4^{Tg(Myh6-CYP2J2)Tr5Dcz}
Transgenic Allele Detail

Summary

• Symbol: Rfx4^{Tg(Myh6-CYP2J2)Tr5Dcz}
• Name: regulatory factor X, 4 (influences HLA class II expression); transgene insertion Tr5, Darryl Zeldin
• MGI ID: MGI:3851404
• Gene: Rfx4 Location: Chr10:84591926-84742402 bp, + strand Genetic Position: Chr10, 41.63 cM, cytoband C1
• Alliance: Rfx4^{Tg(Myh6-CYP2J2)Tr5Dcz} page

Transgene origin

• Strain of Origin: C57BL/6NTac

Transgene description

• Transgene Type: Transgenic (Hypomorph, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Two tandem copies of concatenated transgene consisting of human CYP2J2 cDNA with mouse alpha-MHC promoter and human growth hormone intron and polyA sequence was inserted into intron of mouse Rfx4 gene. This transgene is one of six lines described in J:101489. Northern blot analysis revealed that variant form of the transcript RFX4_v3 expression was absent in brain whereas other two forms, variant 1 and 2, expression were not affected. This is an isoform specific null allele. (J:84751)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rfx4 Mutation: 48 strains or lines available

References

• Original: J:84751 Blackshear PJ, et al., Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. Development. 2003 Oct;130(19):4539-52
• All: 4 reference(s)