Pde1ctm1.1Hazh
Targeted Allele Detail
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Symbol: |
Pde1ctm1.1Hazh |
Name: |
phosphodiesterase 1C; targeted mutation 1.1, Haiqing Zhao |
MGI ID: |
MGI:3851438 |
Gene: |
Pde1c Location: Chr6:56046789-56629472 bp, - strand Genetic Position: Chr6, 27.65 cM
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Alliance: |
Pde1ctm1.1Hazh page
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Germline Transmission: |
Earliest citation of germline transmission:
J:150514
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Parent Cell Line: |
MC1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: The targeting vector was designed to replace exons 5-8, which encodes the N-terminal portion of the predicted catalytic domain, with a floxed neomycin cassette and to insert a stop codon in the remainder of exon 5. Founder mice were crossed with cre transgenic mice to remove the neomycin cassette. No protein product was detected in the cilia layer of homozygote olfactory epithelium as determined by immunohistochemistry.
(J:150514)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pde1c Mutation: |
36 strains or lines available
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Original: |
J:150514 Cygnar KD, et al., Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons. Nat Neurosci. 2009 Apr;12(4):454-62 |
All: |
5 reference(s) |
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