Pde4a^tm1.1Hazh
Targeted Allele Detail

Summary

• Symbol: Pde4a^tm1.1Hazh
• Name: phosphodiesterase 4A, cAMP specific; targeted mutation 1.1, Haiqing Zhao
• MGI ID: MGI:3851439
• Gene: Pde4a Location: Chr9:21077010-21124544 bp, + strand Genetic Position: Chr9, 7.73 cM
• Alliance: Pde4a^tm1.1Hazh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150514
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector was designed to replace exons 9-14 and part of exon 15, which encode the entire predicted catalytic domain, with a floxed neomycin cassette. Founder mice were crossed with cre transgenic mice to remove the neomycin cassette. No protein product was detected in homozygote olfactory epithelium as determined by immunohistochemistry. (J:150514)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde4a Mutation: 39 strains or lines available

References

• Original: J:150514 Cygnar KD, et al., Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons. Nat Neurosci. 2009 Apr;12(4):454-62
• All: 2 reference(s)