Tg(Cd4-Maf)6666Glm
Transgene Detail

Summary

• Symbol: Tg(Cd4-Maf)6666Glm
• Name: transgene insertion 6666, Laurie H Glimcher
• MGI ID: MGI:3851458
• Synonyms: 6666, mafTG
• Transgene: Tg(Cd4-Maf)6666Glm Location: unknown
• Alliance: Tg(Cd4-Maf)6666Glm page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cd4-Maf)6666Glm expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Maf (MGI:96909)

• Mutation details: A 4-kb full length cDNA encoding the c-maf (Maf) gene was cloned into a vector containing the Cd4 promoter-enhancer and first intron without the silencer element. This construct was injected into C57BL/6 blastocysts. 6 founders were obtained and three low copy number transgenics transmitted the transgene to progeny. Lines 6666 (with moderately high levels of Maf tg mRNA in thymus and low levels in spleen) and 6272 (with very low levels of Maf transgenic mRNA in thymus and spleen) were characterized further (J:95878)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:94878 Ho IC, et al., c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms. J Exp Med. 1998 Nov 16;188(10):1859-66
• All: 5 reference(s)