Efnb3^tm3.1Henk
Targeted Allele Detail

Summary

• Symbol: Efnb3^tm3.1Henk
• Name: ephrin B3; targeted mutation 3.1, Mark Henkemyer
• MGI ID: MGI:3851478
• Synonyms: Efnb3^5F
• Gene: Efnb3 Location: Chr11:69444918-69451031 bp, - strand Genetic Position: Chr11, 42.8 cM
• Alliance: Efnb3^tm3.1Henk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150550
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions in exon 5 replace five tyrosines with phenylalanine at positions 311, 318, 323, 337, and 338 (p.Y311F, p.Y318F, p.Y323F, p.(Y337_Y338delinsFF)). A loxP site flanked neomycin resistance gene cassette that was inserted into intron 4 was removed through subsequent cre-mediated recombination. (J:150550)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efnb3 Mutation: 11 strains or lines available

References

• Original: J:150550 Xu NJ, et al., Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning. Nat Neurosci. 2009 Mar;12(3):268-76
• All: 1 reference(s)