Tg(Myh6-Map2k3*)1Jmol
Transgene Detail

Summary

• Symbol: Tg(Myh6-Map2k3*)1Jmol
• Name: transgene insertion 1, Jeffery D Molkentin
• MGI ID: MGI:3851571
• Synonyms: dnMKK3
• Transgene: Tg(Myh6-Map2k3*)1Jmol Location: unknown
• Alliance: Tg(Myh6-Map2k3*)1Jmol page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Map2k3*)1Jmol expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Map2k3 (MGI:1346868)

• Mutation details: he mouse cardiac alpha myosin heavy chain (Myh6) promoter drives expression of a dominant negative Ser189Ala/Ser193Ala form of mouse MKK3 (Map2k3). Two lines were generated and one was chosen for further characterization. (J:83547)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:83547 Braz JC, et al., Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. J Clin Invest. 2003 May;111(10):1475-86
• All: 1 reference(s)