Cngb1^tm1Sjpi
Targeted Allele Detail

Summary

• Symbol: Cngb1^tm1Sjpi
• Name: cyclic nucleotide gated channel beta 1; targeted mutation 1, Steven J Pittler
• MGI ID: MGI:3851598
• Synonyms: Cngb1-X1 KO
• Gene: Cngb1 Location: Chr8:95965673-96033213 bp, - strand Genetic Position: Chr8, 47.12 cM
• Alliance: Cngb1^tm1Sjpi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150504
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment including exons 1 and 2 was replaced with a pgk-neo cassette via homologous recombination. Northern blot analysis confirmed the absence of RNA expression in homozygous mice. Western blot analysis confirmed the absence of protein expression in rod outer segments from homozygous mice. (J:150504)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cngb1 Mutation: 61 strains or lines available

References

• Original: J:150504 Zhang Y, et al., Knockout of GARPs and the beta-subunit of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrity. J Cell Sci. 2009 Apr 15;122(Pt 8):1192-200
• All: 9 reference(s)