Tg(Myh6-Mapk8*,Myh6-Mapk9*)22.4Jmol
Transgene Detail

Summary

• Symbol: Tg(Myh6-Mapk8*,Myh6-Mapk9*)22.4Jmol
• Name: transgene insertion 22.4, Jeffery D Molkentin
• MGI ID: MGI:3851796
• Synonyms: dnJNK1/2, JNK1/2dn
• Transgene: Tg(Myh6-Mapk8*,Myh6-Mapk9*)22.4Jmol Location: unknown
• Alliance: Tg(Myh6-Mapk8*,Myh6-Mapk9*)22.4Jmol page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Dominant negative JNK1 (Mapk8) and JNK2 (Mapk9) cDNAs in which the dual phosphorylation motif TPY was changed to APF were each fused to a 5.5 kb cardiac specific alpha myosin heavy chain promoter. The constructs were mixed and coinjected into FVB/N oocytes. Three independent lines including 22.4 which was chosen as a representative, and 6.1 were found to coexpress equal amounts of each dominant negative protein. (J:85947)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:85947 Liang Q, et al., c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling. EMBO J. 2003 Oct 1;22(19):5079-89
• All: 2 reference(s)