Atr^tm1Twgl
Targeted Allele Detail

Summary

• Symbol: Atr^tm1Twgl
• Name: ataxia telangiectasia and Rad3 related; targeted mutation 1, Thomas W Glover
• MGI ID: MGI:3851820
• Synonyms: Atr^SckN
• Gene: Atr Location: Chr9:95739650-95833834 bp, + strand Genetic Position: Chr9, 50.27 cM, cytoband E4
• Alliance: Atr^tm1Twgl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150723
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Humanized sequence, Hypomorph) Mutations: Insertion, Single point mutation Mutation details: A transition mutation in exon 9 replaces a G with an A. This mutation replicates one identified in human patients with Seckel syndrome 1 that disrupts splicing. Reduced protein expression was confirmed by western blot analysis on spleen, kidney, and brain extracts. (J:150723)

Generation of the Atr^tm1Twgl allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atr Mutation: 133 strains or lines available

References

• Original: J:150723 Ragland RL, et al., Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response. Mamm Genome. 2009 Jun;20(6):375-85
• All: 1 reference(s)