Rr29^Dz
Chemically induced Allele Detail

Summary

• Symbol: Rr29^Dz
• Name: regulatory region 29; preaxial polydactyly
• MGI ID: MGI:3851923
• Synonyms: DZ^m, Shh^Dz
• Gene: Rr29 Location: Chr5:29519879-29520665 bp
• Alliance: Rr29^Dz page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Modified regulatory region)
• Mutation: Single point mutation
• Mutation details: A single point mutation, 8545T>A, was induced by ENU treatment in the cis regulatory element (mammals-fish-conserved-sequence 1, Mfcs1) located 1 Mb upstream of the Shh gene it regulates in intron 5 of Lmbr1. Analysis indicates this mutation increases the binding affinity of Hnrnpu for the core DNA element. In situ analysis detected ectopic expression of Shh in limb buds of homozygous mice at E12. (J:150728)
• Inheritance: Dominant

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr29 Mutation: 2 strains or lines available

References

• Original: J:150728 Zhao J, et al., HnRNP U mediates the long-range regulation of Shh expression during limb development. Hum Mol Genet. 2009 Aug 15;18(16):3090-7
• All: 1 reference(s)