Npas3^tm1Mesu
Targeted Allele Detail

Summary

• Symbol: Npas3^tm1Mesu
• Name: neuronal PAS domain protein 3; targeted mutation 1, Mary E Sunday
• MGI ID: MGI:3852356
• Gene: Npas3 Location: Chr12:53294940-54118958 bp, + strand Genetic Position: Chr12, 22.31 cM, cytoband C1
• Alliance: Npas3^tm1Mesu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150793
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 4 was replaced with a neo cassette. This deletion is predicted to produce a protein lacking part of the PAS-A domain and all of the PAS-B domain. The absence of transcript expression was confirmed by QRT-PCR on E12.5 lung extracts. (J:150793)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npas3 Mutation: 41 strains or lines available

References

• Original: J:150793 Zhou S, et al., NPAS3 is a trachealess homolog critical for lung development and homeostasis. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11691-6
• All: 2 reference(s)