Fcamr^tm2Shib
Targeted Allele Detail

Summary

• Symbol: Fcamr^tm2Shib
• Name: Fc receptor, IgA, IgM, high affinity; targeted mutation 2, Akira Shibuya
• MGI ID: MGI:3852360
• Gene: Fcamr Location: Chr1:130728639-130742477 bp, + strand Genetic Position: Chr1, 56.89 cM, cytoband F
• Alliance: Fcamr^tm2Shib page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150824
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neomycin cassette replaced exons 1-7 of the gene locus in a BALB/c ES cell line. Gene inactivation was confirmed in homozygotes by a lack of signal detected by flow cytometry on B cells. (J:150824)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcamr Mutation: 41 strains or lines available

References

• Original: J:150824 Honda S, et al., Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11230-5
• All: 5 reference(s)