Mrgprd^{tm1.1(cre)And}
Targeted Allele Detail

Summary

• Symbol: Mrgprd^{tm1.1(cre)And}
• Name: MAS-related GPR, member D; targeted mutation 1.1, David Anderson
• MGI ID: MGI:3852395
• Synonyms: Mrgprd-Cre^-
• Gene: Mrgprd Location: Chr7:144868572-144877796 bp, + strand Genetic Position: Chr7, 89.06 cM
• Alliance: Mrgprd^{tm1.1(cre)And} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150802
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Mrgprd^{tm1.1(cre)And} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mrgprd (MGI:3033142)

• Mutation details: Most of the open reading frame was replaced with a cassette containing EGFP, cre, and frt flanked neo that was inserted out of frame with the initiation site. The inserted cassette replaced amino acids 20 through 315 of the total 321 amino acids of the endogenous protein. Germ line, flp mediated recombination removes the neo cassette. (J:150802)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mrgprd (mouse) Summary of all recombinase alleles driven by Mrgprd. Alliance mouse Mrgprd gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mrgprd Mutation: 26 strains or lines available

References

• Original: J:150802 Rau KK, et al., Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors. J Neurosci. 2009 Jul 1;29(26):8612-9
• All: 11 reference(s)