Syna^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Syna^tm1.1Ics
• Name: syncytin a; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:3852417
• Synonyms: SynA^-, Syna^tm1.1Thei
• Gene: Syna Location: Chr5:134587000-134589025 bp, - strand Genetic Position: Chr5, 74.67 cM
• Alliance: Syna^tm1.1Ics page

Growth retardation and decreased vascularization of E13.5 Syna^tm1.1Ics/Syna^tm1.1Ics embryos

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150813
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre and flp mediated recombination was used to remove the neo cassette and the open reading frame. (J:150813)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syna Mutation: 29 strains or lines available

References

• Original: J:150813 Dupressoir A, et al., Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12127-32
• All: 2 reference(s)