Ptpn11^tm1.1Rbns
Targeted Allele Detail

Summary

• Symbol: Ptpn11^tm1.1Rbns
• Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1.1, Jeffrey Robbins
• MGI ID: MGI:3852440
• Synonyms: SHP2^loxP
• Gene: Ptpn11 Location: Chr5:121268596-121329460 bp, - strand Genetic Position: Chr5, 61.72 cM, cytoband F
• Alliance: Ptpn11^tm1.1Rbns page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150835
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Germ line, frt mediated recombination removed the neo cassette leaving exons 3 and 4 floxed. (J:150835)

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn11 Mutation: 46 strains or lines available

References

• Original: J:150835 Nakamura T, et al., Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11270-5
• All: 2 reference(s)