Sox17^{tm1(icre)Heli}
Targeted Allele Detail

Summary

• Symbol: Sox17^{tm1(icre)Heli}
• Name: SRY (sex determining region Y)-box 17; targeted mutation 1, Heiko Lickert
• MGI ID: MGI:3852645
• Synonyms: Sox17^iCre, Sox17^iCredeltaneo, Sox17^tm1(icre)Lic
• Gene: Sox17 Location: Chr1:4561154-4567577 bp, - strand Genetic Position: Chr1, 1.65 cM
• Alliance: Sox17^{tm1(icre)Heli} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150862
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Sox17^{tm1(icre)Heli} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sox17 (MGI:107543)

• Mutation details: A targeting vector containing a mini gene locus with a codon improved cre recombinase cDNA with a translational stop codo, splice donor site, artificial intron and an exon encoding the SV40 polyadenylation signal followed by an FRT-flanked PGK-neo cassette in the opposite orientation was introduced into exon 1 of Sox17 by homologous recombination in TBV2 ES cells. Germline chimeras were generated and the neo cassette was excised by crossing these with Flpe mice. (J:150862)

Generation of the Sox17^{tm1(icre)Heli} allele

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sox17 (mouse) Summary of all recombinase alleles driven by Sox17. Comparative matrix view of recombinase activities Alliance mouse Sox17 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox17 Mutation: 29 strains or lines available

References

• Original: J:150862 Liao WP, et al., Generation of a mouse line expressing Sox17-driven Cre recombinase with specific activity in arteries. Genesis. 2009 Jul;47(7):476-83
• All: 3 reference(s)