Ash1l^{Gt(AL0395)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Ash1l^{Gt(AL0395)Wtsi}
• Name: ASH1 like histone lysine methyltransferase; gene trap AL0395, Wellcome Trust Sanger Institute
• MGI ID: MGI:3852878
• Synonyms: Ash1l^GT
• Gene: Ash1l Location: Chr3:88857929-88986682 bp, + strand Genetic Position: Chr3, 39.01 cM
• Alliance: Ash1l^{Gt(AL0395)Wtsi} page

Mutation origin

• Mutant Cell Line: AL0395
• Germline Transmission: Earliest citation of germline transmission: J:222720
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Hypomorph)
• Mutation: Insertion of gene trap vector Vector: pGT0lxr
• Mutation details: A gene trap vector, pGT01xf, containing the beta-geo reporter gene (beta-galactosidase and neomycin resistance fusion gene) was inserted into intron 1 of the Ash1l gene. Immunohistochemical analysis of uterus tissue from 3 and 4 week old homozygous females and epididymis from homozygous males also shows diminished Ash1l protein. (J:222720)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  AL0395	CL865927 ; (MGI Seq Detail)	5' RACE	Chr3:88873155-88873634 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  14 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ash1l Mutation: 138 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 5 reference(s)