Fto^{Gt(RRZ624)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Fto^{Gt(RRZ624)Byg}
• Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap RRZ624, BayGenomics
• MGI ID: MGI:3853459
• Synonyms: Fto^gt
• Gene: Fto Location: Chr8:92040153-92395067 bp, + strand Genetic Position: Chr8, 44.34 cM
• Alliance: Fto^{Gt(RRZ624)Byg} page

Mutation origin

• Mutant Cell Line: RRZ624
• Germline Transmission: Earliest citation of germline transmission: J:166984
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT2Lxf Vector Type: gene trap
• Mutation details: The gene trap allele inserted between exon 2 and 3. Reduced protien expression was confirmed by western blot analysis on brown adipose, white adipose, and skeletal muscle extracts. (J:166984)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRZ624	CL903364 ; (MGI Seq Detail)	5' RACE	Chr8:92040172-92128508 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  37 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fto Mutation: 75 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 3 reference(s)