Cip2a^{Gt(CD0252)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Cip2a^{Gt(CD0252)Wtsi}
• Name: cell proliferation regulating inhibitor of protein phosphatase 2A; gene trap CD0252, Wellcome Trust Sanger Institute
• MGI ID: MGI:3864546
• Synonyms: CIP2A^HOZ
• Gene: Cip2a Location: Chr16:48814548-48840072 bp, + strand Genetic Position: Chr16, 30.75 cM
• Alliance: Cip2a^{Gt(CD0252)Wtsi} page

Decreased epididymis size in Cip2a^{Gt(CD0252)Wtsi}/Cip2a^{Gt(CD0252)Wtsi} mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: CD0252
• Germline Transmission: Earliest citation of germline transmission: J:187134
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Hypomorph)
• Mutation: Insertion of gene trap vector Vector: pGT0lxfT2
• Mutation details: The gene trap vector inserted into intron 1. RT-PCR indicates a strong reduction (around 90%) in mRNA expression in tissues from homozygous mice. This is a hypomorphic allele. (J:187134)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  CD0252	CZ259400 ; (MGI Seq Detail)	5' RACE	Chr16:48814567-48814741 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  8 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Gene-trap strategy for the Cip2a^{Gt(CD0252)Wtsi} allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cip2a Mutation: 44 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)