Ptpn23^{Gt(YHB130)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Ptpn23^{Gt(YHB130)Byg}
• Name: protein tyrosine phosphatase, non-receptor type 23; gene trap YHB130, BayGenomics
• MGI ID: MGI:3870117
• Synonyms: Ptpn23^-
• Gene: Ptpn23 Location: Chr9:110214152-110237278 bp, - strand Genetic Position: Chr9, 59.92 cM
• Alliance: Ptpn23^{Gt(YHB130)Byg} page

Mutation origin

• Mutant Cell Line: YHB130
• Germline Transmission: Earliest citation of germline transmission: J:153790
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: Trapped gene association determined by genome coordinate overlap and strand. The mouse YHB-130 embryonic stem cell line contains an in frame beta-geo (beta-galactosidase-neomycin-phosphotransferase II) insertion between exons 16 and 17, which leads to the expression of a fusion protein encompassing amino acid residues 1 to 548 (out of 1692 amino acids) fused to beta-geo. Northern blot and Western blot confirmed the presence of the larger transcript and the fusion protein. (J:153790)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  YHB130	DU532914 ; (MGI Seq Detail)	5' RACE	Chr9:110218641-110218741 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  8 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:

72 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn23 Mutation: 59 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)