About   Help   FAQ
Letm1Gt(CC0204)Wtsi
Gene trapped Allele Detail
Summary
Symbol: Letm1Gt(CC0204)Wtsi
Name: leucine zipper-EF-hand containing transmembrane protein 1; gene trap CC0204, Wellcome Trust Sanger Institute
MGI ID: MGI:3870303
Synonyms: Letm1-
Gene: Letm1  Location: Chr5:33897017-33940061 bp, - strand  Genetic Position: Chr5, 17.83 cM
Alliance: Letm1Gt(CC0204)Wtsi page
Small size and decreased cell proliferation in Letm1Gt(DD0926)Wtsi/Letm1+ and Letm1Gt(CC0204)Wtsi/Letm1+ mouse embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Line:  CC0204
Germline Transmission:  Earliest citation of germline transmission: J:222017
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Sanger Inst. Gene Trap Res.
Mutation
description
Allele Type:    Gene trapped (Null/knockout)
Mutation:    Insertion of gene trap vector     Vector: pGT0lxfT2
 
Mutation detailsThe exogenous gene-trap vector sequence, containing an in-frame splice acceptor site followed by coding sequence for a beta-galactosidase/neomycin (beta-Geo) fusion protein, was inserted into the intron following exon 3 (CC0204). The insertion of a trapping vector after exon 3 creates fusion transcripts and premature stop codons, thus preventing the synthesis of full-length mRNA. Full-length mRNA levels are reduced by 50% in heterozygous mutant mice. (J:222017)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Generation of the Letm1Gt(DD0926)Wtsi and Letm1Gt(CC0204)Wtsi alleles
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Letm1 Mutation:  27 strains or lines available
References
Original:  J:222017 Jiang D, et al., Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2249-54
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory