Casz1Gt(CJ0565)Wtsi
Gene trapped Allele Detail
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Symbol: |
Casz1Gt(CJ0565)Wtsi |
Name: |
castor zinc finger 1; gene trap CJ0565, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:3870873 |
Synonyms: |
Casz1betageo |
Gene: |
Casz1 Location: Chr4:148888886-149039346 bp, + strand Genetic Position: Chr4, 78.87 cM
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Alliance: |
Casz1Gt(CJ0565)Wtsi page
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Edema, heart failure, and heart abnormalities in E16.5 Casz1Gt(CJ0565)Wtsi/Casz1Gt(CJ0565)Wtsi fetuses
Show the 7 phenotype image(s) involving this allele.
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Mutant Cell Line: |
CJ0565 |
Germline Transmission: |
Earliest citation of germline transmission:
J:242127
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Parent Cell Line: |
E14TG2a.4 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Project Collection: |
Sanger Inst. Gene Trap Res.
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Allele Type: |
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Gene trapped (Null/knockout, Reporter) |
Mutation: |
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Insertion of gene trap vector
Vector: pGT0lxrT2
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Mutation details: A gene trap containing a beta-geo reporter inserted into the sequences after exon 9, resulting in a truncated protein in which 10 of the 11 zinc fingers are lost. Real time PCR analysis revealed no detectable mRNA in the heart of E12.5 homozygous mutant embryos. Western blot analysis confirmed the absence of protein expression of both the full-length (Casz1a) and shorter (Casz1b) isoform in E14.5 whole heart lysates.
(J:242127)
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Sequence Tags: |
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Sequence tag details (1 tag)
Tag ID |
GenBank ID |
Method |
Tag Location (trapped strand)* |
Select |
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Generation of the Casz1Gt(CJ0565)Wtsi allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Casz1 Mutation: |
345 strains or lines available
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Original: |
J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008; |
All: |
2 reference(s) |
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