Brk1^{Gt(DC0002)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Brk1^{Gt(DC0002)Wtsi}
• Name: BRICK1, SCAR/WAVE actin-nucleating complex subunit; gene trap DC0002, Wellcome Trust Sanger Institute
• MGI ID: MGI:3872157
• Gene: Brk1 Location: Chr6:113581733-113593912 bp, + strand Genetic Position: Chr6, 52.81 cM
• Alliance: Brk1^{Gt(DC0002)Wtsi} page

Mutation origin

• Mutant Cell Line: DC0002
• Germline Transmission: Earliest citation of germline transmission: J:166082
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1lxr
• Mutation details: The gene trap vector inserted into intron 1 between positions 10,139,050 and 10,139,051. The mutant transcript includes the first 42 amino acids of the gene fused to the beta-geo and noemyocin resistance genes. (J:166082)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  DC0002	DU709680 ; (MGI Seq Detail)	5' RACE	Chr6:113581718-113581856 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  20 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brk1 Mutation: 16 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 2 reference(s)