Smg1^{Gt(AG0297)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Smg1^{Gt(AG0297)Wtsi}
• Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase; gene trap AG0297, Wellcome Trust Sanger Institute
• MGI ID: MGI:3876748
• Gene: Smg1 Location: Chr7:117730531-117842893 bp, - strand Genetic Position: Chr7, 63.44 cM
• Alliance: Smg1^{Gt(AG0297)Wtsi} page

Lymphoma, chronic inflammation, papillary adenocarcinoma, and steatosis in Smg1^{Gt(AG0297)Wtsi}/Smg1⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: AG0297
• Germline Transmission: Earliest citation of germline transmission: J:193626
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0lxr
• The gene trap vector inserted into intron 4. (J:193626)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  AG0297	DX574227 ; (MGI Seq Detail)	5' RACE	Chr7:117809961-117812240 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  48 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Generation of the Smg1^{Gt(AG0297)Wtsi} allele

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smg1^{Gt(AG0297)Wtsi}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Smg1 Mutation: 224 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 3 reference(s)