Arfgef1Gt(CSH465)Byg
Gene trapped Allele Detail
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Symbol: |
Arfgef1Gt(CSH465)Byg |
Name: |
ARF guanine nucleotide exchange factor 1; gene trap CSH465, BayGenomics |
MGI ID: |
MGI:3878593 |
Synonyms: |
Arfgef1geo, BIG1-deficient |
Gene: |
Arfgef1 Location: Chr1:10207796-10302895 bp, - strand Genetic Position: Chr1, 2.36 cM
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Alliance: |
Arfgef1Gt(CSH465)Byg page
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Mutant Cell Line: |
CSH465 |
Germline Transmission: |
Earliest citation of germline transmission:
J:248338
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Parent Cell Line: |
Other (see notes) (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Gene trapped (Null/knockout) |
Mutation: |
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Insertion of gene trap vector
Vector: pGT0Lxf
Vector Type: gene trap
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Mutation details: The gene trap cassette was inserted between exon 35 and exon 36, corresponding to sequences encoding the C-terminus of the protein. The encoded protein is undetectable in homozygous mutant brains using antibody against an N-terminal epitope or a C-terminal epitope, confirming the complete absence of the encoded protein for this allele.
(J:248338)
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Sequence Tags: |
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Sequence tag details (1 tag)
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Genome Context: |
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Genome Browser view of this mutation
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: 129P2/OlaHsd * C57BL/6J | |
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Phenotypes: |
Affected Systems |
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behavior/neurological
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absent gastric milk in neonates
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cellular
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increased neuron apoptosis
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abnormal neuron differentiation
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abnormal axon extension
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delayed axon extension
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abnormal axon guidance
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mortality/aging
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neonatal lethality, complete penetrance
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nervous system
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increased neuron apoptosis
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abnormal neuron differentiation
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abnormal axon extension
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delayed axon extension
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abnormal axon guidance
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decreased brain size
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enlarged lateral ventricles
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abnormal corpus callosum morphology
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absent anterior commissure
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small hippocampus
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decreased neocortex size
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thin cerebral cortex
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small cerebellum
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√
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abnormal glutaminergic neuron morphology
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Arfgef1 Mutation: |
104 strains or lines available
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All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
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Original: |
J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008; |
All: |
3 reference(s) |
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