Arf4^{Gt(CSH658)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Arf4^{Gt(CSH658)Byg}
• Name: ARF GTPase 4; gene trap CSH658, BayGenomics
• MGI ID: MGI:3879059
• Gene: Arf4 Location: Chr14:26359289-26377997 bp, + strand Genetic Position: Chr14, 16.09 cM
• Alliance: Arf4^{Gt(CSH658)Byg} page

Decreased dendritic spine density in Arf4^{Gt(CSH658)Byg}/Arf4⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: CSH658
• Germline Transmission: Earliest citation of germline transmission: J:192108
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: The gene trap vector inserted into intron 1. Western blot analysis confirmed a 49% reduction in protein expression in the hippocampus of heterozygous mice. (J:192108)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  CSH658	ED033814 ; (MGI Seq Detail)	5' RACE	Chr14:26359294-26359580 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  11 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Schematic of the gene trap Arf4^{Gt(CSH658)Byg} allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arf4 Mutation: 20 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 3 reference(s)