Suco^{Gt(KST050)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Suco^{Gt(KST050)Byg}
• Name: SUN domain containing ossification factor; gene trap KST050, BayGenomics
• MGI ID: MGI:4123936
• Gene: Suco Location: Chr1:161643683-161704251 bp, - strand Genetic Position: Chr1, 69.95 cM
• Alliance: Suco^{Gt(KST050)Byg} page

Suco^{Gt(KST050)Byg}/Suco^{Gt(KST050)Byg} mice exhibit growth retardation and low bone mass with multiple fractures

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: KST050
• Germline Transmission: Earliest citation of germline transmission: J:159823
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0TMpf Vector Type: secretory trap
• Mutation details: The gene trap vector inserted at bp 1624 in intron 11. RT-PCR and northern blot analysis confirmed the absence of full length transcript in homozygous embryos. Immunoblot analysis detected negligible amounts of protein in homozygous whole embryo lysates. Beta-galactosidase activity was detected in all skeletal elements of newborn heterozygotes. (J:159823)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  KST050	CC144631 ; (MGI Seq Detail)	5' RACE	Chr1:161674773-161680502 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  8 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Suco Mutation: 49 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 3 reference(s)