Foxn3^Gt(XE749)Byg
Gene trapped Allele Detail

Summary

• Symbol: Foxn3^Gt(XE749)Byg
• Name: forkhead box N3; gene trap XE749, BayGenomics
• MGI ID: MGI:4126144
• Synonyms: Foxn3^H
• Gene: Foxn3 Location: Chr12:99156337-99529841 bp, - strand Genetic Position: Chr12, 49.93 cM, cytoband F1
• Alliance: Foxn3^Gt(XE749)Byg page

Mutation origin

• Mutant Cell Line: XE749
• Germline Transmission: Earliest citation of germline transmission: J:164801
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Hypomorph, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: The gene-trap (containing a betageo reporter-selection gene cassette) inserted 13,940 bases from the start intron 3. This leads to the putative generation of a truncated fusion protein with betageo containing the first 218 amino acids (including part of the fork-head box domain) of the target gene and the loss of C-terminal 239 amino acids (containing part of the fork-head box domain and the SIN3 binding domain). Homozygous mutants expressed low levels of the native gene indicating the generation of a hypomorphic allele. (J:164801)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XE749	CC183338 ; (MGI Seq Detail)	5' RACE	Chr12:99245105-99307717 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  52 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxn3 Mutation: 30 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 3 reference(s)