Srgap2^Gt(XH102)Byg
Gene trapped Allele Detail

Summary

• Symbol: Srgap2^Gt(XH102)Byg
• Name: SLIT-ROBO Rho GTPase activating protein 2; gene trap XH102, BayGenomics
• MGI ID: MGI:4126449
• Gene: Srgap2 Location: Chr1:131212989-131455090 bp, - strand Genetic Position: Chr1, 56.93 cM, cytoband E4
• Alliance: Srgap2^Gt(XH102)Byg page

Mutation origin

• Mutant Cell Line: XH102
• Germline Transmission: Earliest citation of germline transmission: J:185134
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Hypomorph, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: A gene trap vector inserted between exons 2 and 3 of the gene. Cortical cells from homozygous mice show a ~90% reduction in the level of expressed normal transcript and protein from this allele. The mutation results in the production of a fusion protein composed of the first 22 aa of SRGAP2 and beta-Geo. (J:185134)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XH102	CC199542 ; (MGI Seq Detail)	5' RACE	Chr1:131441911-131442038 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  53 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Srgap2 Mutation: 79 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 6 reference(s)