Akap12^Gt(XE450)Byg
Gene trapped Allele Detail

Summary

• Symbol: Akap12^Gt(XE450)Byg
• Name: A kinase anchor protein 12; gene trap XE450, BayGenomics
• MGI ID: MGI:4126493
• Synonyms: gravin-t
• Gene: Akap12 Location: Chr10:4216380-4309470 bp, + strand Genetic Position: Chr10, 2.06 cM
• Alliance: Akap12^Gt(XE450)Byg page

Mutation origin

• Mutant Cell Line: XE450
• Germline Transmission: Earliest citation of germline transmission: J:207542
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: The gene trap vector inserted into intron 2. Western blot analysis confirmed reduced protein expression in the left ventricle. (J:207542)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XE450	CC199592 ; (MGI Seq Detail)	5' RACE	Chr10:4216328-4263855 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  269 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akap12 Mutation: 215 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 5 reference(s)