Wtip^Gt(XH617)Byg
Gene trapped Allele Detail

Summary

• Symbol: Wtip^Gt(XH617)Byg
• Name: WT1 interacting protein; gene trap XH617, BayGenomics
• MGI ID: MGI:4126568
• Synonyms: Wtip^beta-geo
• Gene: Wtip Location: Chr7:33808968-33832693 bp, - strand Genetic Position: Chr7, 19.4 cM
• Alliance: Wtip^Gt(XH617)Byg page

Mutation origin

• Mutant Cell Line: XH617
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: The insertion of a promoterless beta-geo casette in intron 2 results in splicing of exon 2 to beta-geo and production of a fusion transcript consisting of exons 1 and 2 with beta-geo. Western blot analysis demonstrated a reduction of protein abundance in glomerular lysates from heterozygous adult mice relative to wild-type controls. (J:327589)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XH617	CC199675 ; (MGI Seq Detail)	5' RACE	Chr7:33824910-33831976 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  2 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wtip Mutation: 19 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)